Boy, good question.
I've got it installed. I only had problem with one script (enom API) that I had to change around when I transferred my site from another server.
This was a big help for me (Googled and found it)
http://www.onlinemalls.com/cp/news.html
I'm not sure . . . seems in my reading a lot of people have it disabled. Me being a dumby will keep it on because I figure the better protection I have the better off I am.
Question becomes, if I transfer accounts who use Fantastico installs on a server with it disabled, do they have to reinstall it after I transfer them to my server with it enabled?
Thanks